Review: taurine: a "very essential" amino acid. Zhu, Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study, Hypertension 67(3) (2016) 541-549. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study. Sun Q., Wang B., Li Y., Sun F., Li P., Xia W., Zhou X., Li Q., Wang X., Chen J., Zeng X., Zhao Z., He H., Liu D., Zhu Z. Smith, Biochemistry and physiology of taurine and taurine derivatives, Physiol Rev 48(2) (1968) 424-511. Biochemistry and physiology of taurine and taurine derivatives. This article also addresses the neuropharmacological potential of taurine analogs.Īnalogs Clinical study and Neurological disorders Molecular role Taurine Therapeutic.Ĭopyright © 2019. Herein, we present an overview on the therapeutic potential of taurine against neurological disorders and highlight clinical studies and its molecular mechanistic roles. Considering current biopharmaceutical limitations, developing novel delivery approaches and new derivatives and precursors of taurine may be an attractive option for treating neurological disorders. Several findings demonstrate its therapeutic role against neurodevelopmental disorders, including Angelman syndrome, Fragile X syndrome, sleep-wake disorders, neural tube defects and attention-deficit hyperactivity disorder. In addition, taurine displays potential ameliorating effects against different neurological disorders such as neurodegenerative diseases, stroke, epilepsy and diabetic neuropathy and protects against injuries and toxicities of the nervous system.
Different cellular processes such as energy metabolism, gene expression, osmosis and quality control of protein are regulated by taurine. Taurine also modulates ER stress, Ca 2+ homeostasis and neuronal activity at the molecular level as part of its broader roles. In the several disease models, it attenuates inflammation- and oxidative stress-mediated injuries. It presents in different organs, including retina, brain, heart and placenta and demonstrates extensive physiological activities within the body. Taurine is a sulfur-containing amino acid and known as semi-essential in mammals and is produced chiefly by the liver and kidney.
0 kommentar(er)
